ABSTRACT

The aim and objective of the present study was to prepare and evaluate a press coated pulsatile drug delivery system of Lovastatin in order to attain a time controlled release, which is used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endogenous production of cholesterol in the liver. The core was prepared by direct compression, while press coating technique was used in coating the outer layer there by preparing a press coated tablet. The immediate release core formulations comprised of Lovastatin and disintegrants like Crosspovidone, lycoat in different ratios with the drug. The outer coat formulations were prepared using a hydrophilic (HPMC) and hydrophobic (EC) polymer of different ratios. All the core and press coated tablets were evaluated for various preformulation and post compression parameters along with the dissolution study that was performed using USP paddle method at 50 rpm in 0.1 N HCl and phosphate buffer pH 6.8. The optimized formulation F9 containing 200 mg of EC and 200 mg of HPMC K15 may be regarded as the minimum quantity required in outer press coat so as to attain a predetermined lag time of 6 h and the drug release was bursted at the end of 7th hour and showed maximum release at the end of 8th hour. It follows first order release and follows fickian diffusion transport mechanism. Keywords: ethyl cellulose, hydroxypropyl methylcellulose, press coat, lovastatin, time-controlled release
Publication date: 01/05/2024

https://ijbpas.com/pdf/2024/May/MS_IJBPAS_2024_8015.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.5.8015