ABSTRACT

The present work was to explore the ability of amphiphilic block copolymer poloxamine (TETRONICS) to form polymeric micelles which acts as an effective drug delivery and targeting system for cancer therapy. The practical disadvantage of poloxamine due to its high CMC & cloud point is overcome by adding inorganic salt such as NaCl .The fabrication of class II drug Nintedanib into polymeric micelle was done by direct dissolution method. The formulation parameters were optimized using design expert software. Compatibility studies for drug and excipients were carried out by Fourier Transform Infrared Spectroscopy (FTIR) and Differential Scanning Calorimetry the designed polymeric micelles were evaluated for its characteristic features like Cloud point, DLS, Entrapment efficiency and In vitro release studies. In vitro cytotoxic activity for its efficiency as a promising drug delivery system was established using MTT assay. The lyophilized form of micelles was examined for its surface morphology using scanning electron microscopy and phase contrast microscopy. The solubilization of anticancer drug nintedanib demonstrates improved controlled release kinetics and cytotoxicity. On the whole, modulation in micellar behaviour by NaCl opens enchanting possibility of using T1307 and T1107 micelles as nanoreservoirs for carrying poorly water soluble drugs. Keywords: Polymeric micelles, amphiphilic block polymer, Tetronics, Design expert, non-small cell lung cancer
Publication date: 01/05/2024

https://ijbpas.com/pdf/2024/May/MS_IJBPAS_2024_8014.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.5.8014