ABSTRACT

The gut, an area of expanding interest, is home to a plethora of microorganisms that are crucial to maintaining normal physiological function in humans, called eubiosis. Many metabolites and immunological reactions in the gut elicit a range of responses, sometimes which can cause negative consequences, causing dysbiosis. These may result in infections, inflammation, the growth of tumors, and other conditions. Current research suggests that there are several ways in which cancer and gut microbiome is interlinked. Stomach cancer, the fifth most prevalent cancer malignancy, has crippling effects brought about by a variety of factors, including age, obesity, food, alcohol, smoking, and infections caused by Helicobacter pylori. These often cause alterations in the composition of the gut. As a result, investigating and comprehending the impact dysbiosis has on gastric cancer and how different factors cause these perturbations can help with better therapeutic approaches and screening to aid in early identification. Attempts to reduce the risks of stomach cancer can be made by conducting more research in many therapeutic areas, such as fecal microbial transplantation and optimizing cancer treatment without or with less dependency on surgical procedures. This review elucidates the influence of dysbiosis and the role that many factors play in the gut microbiota, which results in gastric cancer. Keywords: Gut microbiome, gastric cancer, factors, dysbiosis, carcinogenesis
Publication date: 01/05/2024

https://ijbpas.com/pdf/2024/May/MS_IJBPAS_2024_8002.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.5.8002