ABSTRACT

Objective: The purpose of the study was to formulate and evaluate polyherbal tablets intended for the treatment of urinary stones. To prevent the recurrence of urinary stones and the painful urination associated with urinary stone diseases. Methods: Tablets were prepared using methanolic leaf extracts of the selected plants, viz. Bryophyllum pinnatum and Amaranthus viridis , with the help of wet granulation techniques using sodium starch glycolate, polyvinylpyrrolidone, and lactose in different percentages. Evaluation assessments such as the substantial test, weight variation, hardness, friability, content uniformity, disintegration, in vitro dissolution, and stability study were carried out. results: For all formulations, the micromeritics of the extract powder were evaluated, indicating satisfactory flow characteristics. It was determined that the substantial examination complies with all official requirements for friability and weight uniformity throughout all formulations. All formulations had disintegration times that ranged from 22 to 32 minutes. Formula 2 (F2) was chosen for in vitro dissolution, which demonstrated 93.57+0.305% drug release. The IR compatibility indicates that there is no chemical interaction between the extracts and excipients. The results of the stability studies showed that the polyherbal tablets were stable over three months. Conclusion: According to the study, the F2 formulation had the best disintegration time and in vitro dissolution. Hence, it was selected as an optimised formulation and subjected to stability study. Stability study results revealed that, formulation F2 was a stable formulation having better disintegration time and %friability and could be used for effective treatment of urinary stones. Keywords: Amaranthus viridis, Bryophyllum pinnatum, Diuretic activity, Antiurolithiatic activity, Polyherbal tablet, Renal calculi, Calcium oxalate stones
Publication date: 01/05/2024

https://ijbpas.com/pdf/2024/May/MS_IJBPAS_2024_8001.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2024/13.5.8001