ABSTRACT

Synthetic pyrethroids are most extensively used pesticides for pest management across the world compared to other classes of pesticides due to its great efficacy, ease of degradability and less toxicity to humans and other animals. Fenpropathrin is a type II synthetic pyrethroid with an alpha cyano moiety and is most commonly used in agriculture, horticulture, household and veterinary medicines to manage ecto-parasites such as ticks, fleas, moths, cockroaches and vegetable pest. It is a non-systemic insecticide mainly applied on fruits, vegetables and crops and behaves as a contact toxin and acts on the nervous system by initiating numerous action potentials which cause delay in closure of sodium ion channels leading to convulsions, paralysis and finally the death of insects. Acute and sub-chronic doses of fenpropathrin administration led to variations in physiology, histology and several biochemical and neurological parameters indicating toxic effects on fishes, insects and mammals. Toxic symptoms of fenpropathrin exposure include irritation of eyes and skin, numbness, oxidative stress, headache, fatigue, dizziness, vomiting, sensation of tingling, diarrhea and unusual facial sensation. This article provides information and an overview of the possible toxicity of fenpropathrin at different dose levels in the experiments conducted by scientists during the last ten years in different animal models, suggesting restricted and judicious usage of fenpropathrin Keywords: Synthetic pyrethroid; Fenpropathrin; Insecticide; Animal model; Toxicity; Non systemic
Publication date: 01/05/2024

https://ijbpas.com/pdf/2024/May/MS_IJBPAS_2024_7998.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.5.7998