ABSTRACT

In an approach to develop potent analgesic agents, we synthesized few of newer quinoxaline derivatives through green synthesis. Final derivatives were screened for their in-vitro and in- vivo anti-bacterial and analgesic activities on different bacterial species like Bacillus subtilis, Staphylococcus epidermititis, Pseudomonas vulgaris, Pseudomonas aeruginosa and animals like Swiss albino mice. All the compounds were characterized by IR and H1 NMR spectroscopic data. By performing the above screening procedures, all the synthesized quinoxaline derivatives are unique compounds that show good responses for both anti-bacterial and analgesic activities. In that, the compounds QX2 and QX3 have shown maximum response for both activities when compared to standard drugs like Ampicillin and Pentazocine. Keywords: Quinoxaline, Anti-bacterial, Green-synthesizer, Analgesic
Publication date: 01/04/2024

https://ijbpas.com/pdf/2024/April/MS_IJBPAS_2024_7967.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.4.7967