ABSTRACT

Various inhibitors have been developed for neuraminidase but resistance against these drugs in many viral strains makes it an advantageous and interesting task to discover compounds which can be more promising in preventing viral infection through neuraminidase. Virtual screening methods have been proved as an efficient in silico approach for drug discovery processes. In the present study, we used ligand based virtual screening process for identifying potent inhibitors against viral neuraminidase enzyme. The approach utilized in this study has been successful in identifying docking results indicate that out of 33 Marine compounds, there were three inhibitory compounds for Neuraminidase as target for swine flu. Thus, our study confirms ZINC2043006, ZINC5884077 and ZINC13802909 are potential inhibitors for Neuraminidase as target for tuberculosis. The results of the present study are reported here in so that researchers, who are having required laboratory facilities for synthesizing drugs, can utilize findings of this study for developing new drugs against Influenza with better efficacy. Keywords: neuraminidase, swine flu, ZINC2043006, ZINC5884077 and ZINC13802909
Publication date: 01/04/2024

https://ijbpas.com/pdf/2024/April/MS_IJBPAS_2024_7962.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2024/13.4.7962