REVIEW ON INSOMNIA – IN-VIVO AND IN-VITRO STUDIES Authors: Mandal SD And Mohanty A*
ABSTRACT
Insomnia may be the only sleep illness for which there has been a significant amount of top-down
theorising. This could be because a framework is needed to understand a disorder with various causes
and a sneaky progression. One of the most common sleep disorders, insomnia, comprises both daytime
complaints and sleep-related issues. For excellent health and a high quality of life, you must get enough
sleep. Despite this, there is a rising global prevalence and burden of insomnia condition, which can be
acute (short-term) or chronic. Animal studies have been extremely helpful in helping us understand
the mechanism of sleep and the causes responsible for sleep disorders, even though human beings are
frequently used as subjects in research on sleep and sleep disorders. The disease of narcolepsy has
likely benefited the most historically from animal studies of sleep disorders because research on mice
and dogs uncovered previously unknown pathways underlying this ailment. This review examines
both in vivo studies of insomnia and in vitro models that cover the key components of sleep.
Keywords: Insomnia, sleeping disorder, tuberos mamillary nucleus (TMN), Hypothalamo-
pituitary-adrenal (HPA) axis, lack of sleep Publication date: 01/04/2024 https://ijbpas.com/pdf/2024/April/MS_IJBPAS_2024_7958.pdfDownload PDFhttps://doi.org/10.31032/IJBPAS/2024/13.4.7958