ABSTRACT

The current research work is undertaken with the aim to formulate and evaluate piroxicam emulgel using Galangal oil which increases the permeation of the drug through the skin. Four different formulations were primped and distinguished physically in the matter of physical appearance like colour, odour, texture, Spreadability, pH, drug content, extrudability and viscoelastic properties. The pH of the prepared formulations was found in between 6.35 to 6.37 which lies in the normal pH range of the skin. The spectra of the pure drug and excipients are determined by ATR-FTIR model. It concludes that the final product is safe and effective and compatible with each other without causing any negative adverse effects and compatible with each other. In-vitro drug release studies was performed and evaluated using Franz diffusion cell. From the obtained results it was concluded that F3 was optimized as it has shown higher drug release and maximum drug content of 93%. In-vivo study was performed to assess the anti-inflammatory effect using a carrageenan-induced rat paw oedema model. It was concluded that inflammation of rat paw was reduced as compared to marketed formulation. The prepared piroxicam emulgel has better anti- inflammatory activity than marketed formulation of diclofenac emulgel.Since emulgels had appeared as a novel technique for topical drug delivery,it can be very efficient for hydrophobic drugs. Keywords: Piroxicam,Emulgel,Galangal oil,Topical drug delivery
Publication date: 01/04/2024

https://ijbpas.com/pdf/2024/April/MS_IJBPAS_2024_7956.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.4.7956