Several models for modelling renal failure are compiled in this article. Medical research has
always placed a high value on the use of animal models. The nepharolithisis and urolithasis
models are also most frequently utilised in mouse and rat experimental procedures. Around
100,000 Americans in the US are diagnosed with ESRD each year, according to epidemiology,
and the risk factors are primarily cirrhosis, obesity and smoking. They also exhibit management
therapy. Then, abstracts show different induction models using induced extracts of various
leaves and plants, including Melia azedarach Linn leaves, methanolic extract of Cucumis melo,
Chenopodium album Linn leaves, G. fruticosus solvent extracts, Urtica dioica methanol
extract, and Hygrophila spinosa. Using various techniques leads to the observation of various
types of activities. The administration techniques employed in induction procedures include
oral, parenteral, and implanted. The outcomes of these techniques show that many parameters
are seen. These strategies are seen and documented together with improvements in renal
tissues, urine volume, oxalate levels, serum creatine, blood urea nitrogen levels, and
hyperoxaluria uric levels. Some techniques increased activity while others caused it to
decrease.
Keywords: Urolithasis, Nepharolithasis, Ethylene glycol, Hyperoxaluria, Kidney,
Animal models, Induction
Publication date: 01/04/2024
https://ijbpas.com/pdf/2024/April/MS_IJBPAS_2024_7796.pdf
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https://doi.org/10.31032/IJBPAS/2024/13.4.7796
