ABSTRACT

Introduction: Harataladi lepa has been indicated in the management of Switra (Vitiligo) by the authentic book of Ayurveda, Baishajya ratnavali. There is no work on record on formulation and standardization aspect of compound formulation Harataladi lepa. This paper highlights the preparation, physico-chemical characterization, TLC and HPTLC densitogram profiling of Harataladi lepa which can be applied for authentication of this herbomineral formulation. Methods: The lepa was prepared by combining Chitraka (Plumbago zeylanica Linn.), Triphala (Emblica officinalis Linn., Terminalia bellerica (Gaertn.) Roxb., Terminalia chebula Retz.), Shodita Haratala (Orpiment (As2S3)), Shodita Kasisa (Green vitriol (FeSO4)), Shodita Gandhaka (Sulphur (S)), Tila taila (Sesame oil), (Madhuchista Bee wax) were subjected for detailed physico-chemical and HPTLC analyses. Results: Set of standardization parameters were derived for the compounded Lepa by physico-chemical characterization. The tests proposed would serve as diagnostic parameters for the identity of this herbomineral formulation. HPTLC fingerprint profile which can serve as a fingerprint for the identification of the formulation has been obtained. Conclusion: The proposed method of making Lepa will aid in yielding concentrated medicament with the same efficacy as per the classically proposed drug dosage at lower dose. Standards for the herbomineral formulation has been developed for the quality check of the formulation. Keywords: Ayurveda, Harataladi lepa, Switra, Skin, Vitiligo, HPTLC densitogram
Publication date: 01/03/2024

https://ijbpas.com/pdf/2024/March/MS_IJBPAS_2024_7878.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.3.7878