ABSTRACT

Marsilea quadrifolia is widely used for the treatment of varieties of skin diseases in the Ayurvedic medicine system, as well as it is also used as folk medicine in wound management. But still there was no scientific data available on wound healing activity of Marsilea quadrifolia . So, we had attempted to investigate this activity. The purpose of this study was to screen the wound healing properties of a hydro-alcoholic extract of Marsilea quadrifolia leaves. In this research study, the hydroalcoholic extract of Marsilea quadrifolia leaves was obtained by percolation method. Two doses of Marsilea quadrifolia (2.5% and 5%) suitable gel formulation was prepared with the help of HPMC as a gel base to apply topically. Evaluation of the wound healing activity was done by “Excision, and Incision wound” models, also we performed skin irritation study. In the excision wound model, rats treated with Marsilea quadrifolia leaves extract showed a significant improvement in the epithelization time and 50%wound contraction. As well as, the breaking strength of rats treated with Marsilea quadrifolia leaves extract increased significantly in an incision wound model as compared to the control group. Marsilea quadrifolia leaves extract gel formulations shown likely similar activities as compared to synthetic standard/marketed povidone-iodine as well as herbal standard Aloe vera gel formulation. Marsilea quadrifolia does not produce any irritation in the skin So, it can be concluded that Marsilea quadrifolia leaves extract (2.5 % and 5% gel formulation) has potent wound healing activity. Keywords: Marsilea quadrifolia , Phytochemicals, Wound healing, Skin irritation study, Excision wound model, Incision wound model
Publication date: 01/02/2024

https://ijbpas.com/pdf/2024/February/MS_IJBPAS_2024_7827.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.2.7827