ABSTRACT

Helminthic infections are among the most human illness affecting among half of the world’s population. In developing nations, they represent a serious threat to public health and increase the risk of pneumonia, eosinophilia, anaemia, and malnutrition. Herbs are the source of different phytoconstituents that are responsible to treat different disease, helminthic infection is one of them. In our traditional medicine system, different herbs are used to treat the helminthic infection, Moringa oleifera is one of them. The present study aimed to evaluate the anthelmintic activity of Moringa oleifera flowers on Tubifex tubifex to find out the minimum lethal dose 100 and compare its anthelmintic activity with albendazole as well as a herbal standard drug within 4 hours. The experiment was conducted using freshly collected Tubifex tubifex, which were exposed to different concentrations of Moringa oleifera flower extract, albendazole, and the herbal standard drug. The anthelmintic activity was determined based on the time taken for paralysis and death of the worms within 4 hours. The results showed that the Moringa oleifera flower extract had a dose-dependent anthelmintic activity on Tubifex tubifex, with a significant reduction in the time taken for paralysis and death of the worms compared to the control group. Furthermore, the anthelmintic activity of Moringa oleifera flowers was found to be comparable to that of albendazole, a known synthetic anthelmintic drug, and the herbal standard drug. Therefore, the present study demonstrates the potential of Moringa oleifera flowers as an effective natural anthelmintic agent. Keywords: Moringa oleifera, hydroalcoholic extract, phytoconstituents, albendazole, herbal standard, anthelmintic activity
Publication date: 01/02/2024

https://ijbpas.com/pdf/2024/February/MS_IJBPAS_2024_7803.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.2.7803