ABSTRACT

When a new solid dosage form is developed it is important to study the drug release pattern. The objective of this review to study the kinetics of drug release from dosage form. Many mathematical models have been used to design a number of simple and complex drug delivery system and to determine the overall release behavior. It is very important to know how to use these equations to understand the release patern. The mathematical modeling help to optimize the design of dosage form. The quantitative analysis of the value obtained in dissolution rates is easier. The choice of selection best model depends upon on the desired predictive ability and accuracy of model. This review gives the idea about the kinetics of drug release namely model dependent like (zero order, first order, Hixson-Crowell, Higuchi, Weibull, Korsemeyer-Peppas, Hopfenberg, Baker-Lonsdale, Gompertz and regression models), statistical analysis (exploratory data analysis method, repeated measures design,t-test, ANOVA, MANOVA etc.) and model independent method [difference factor(f1),similarity factor(f2)] can be used. Keywords: ANOVA, Hixson-Crowell Gompertz model, SUPAC, MANOVA
Publication date: 01/02/2024

https://ijbpas.com/pdf/2024/February/MS_IJBPAS_2024_7789.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.2.7789