ABSTRACT

Oxidative mechanisms play a major role in the aetiology and pathogenesis of cataract. The aim of present study is to investigate the activity of antioxidant enzyme catalase and the level of antioxidant compound uric acid in patients with diabetic and senile cataract and compare them. Total of 115 patients were included in this study out of which 40 diabetic cataract and 75 senile cataract patients attending by the Ophthalmology OPD of Shri Mahant Indresh hospital, Dehradun. Plasma/serum sample from diabetic and senile patients suffering from cataract were assessd for blood glucose, catalase, and uric acid levels. Whole blood for HbA1c levels was assessed. The activity of catalase (CAT) was significantly decreased in diabetic cataract patients in comparison to patients with senile cataracts (p<0.001). Concentration of serum uric acid is significantly increased in diabetic cataract patients as compared to senile catract patients (<0.001). Fasting and post-parandial blood glucose levels in patients of diabetic cataract were significantly higher (p<0.001) as compared to the patients of senile cataract. The current study revealed that oxidative stress indicated by decrease activity of antioxidant enzyme catalase and increased concentration of uric acid, might have a role in diabetes related complication specifically cataract formation. Keywords: Oxidative stress, Antioxidant, Cataract, CAT, Diabetes
Publication date: 01/02/2024

https://ijbpas.com/pdf/2024/February/MS_IJBPAS_2024_7786.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.2.7786