ABSTRACT

Standardization of crude drugs is a code of conduct and an essential need of a time. The broad spectrum of standardization gives surety of correct substance in correct amount for desired therapeutic effects. It also provides all possible careful measures taken from collection, manufacturing till drug dispensing for clinical application. The plant selected for the present investigation is Premna serratifolia, belonging to the family Lamiaceae. The aerial parts of the plant were shade dried and ground to fine powder and subjected to organoleptic, fluorescent and physico-chemical analysis. The plant powder was subjected to Soxhlet extraction using methanol as the solvent. Phytochemical screening (Qualitative and Quantitative) of the plant extract was done according to the standard biochemical procedures. Anti-inflammatory activity of the plant extract was tested using Albumin denaturation assay. The organoleptic analysis revealed the characteristic colour, taste, odour and nature of the powder of Premna serratifolia. In fluorescence analysis, on treatment with different solvents, colour changes (specific) could be noticed in the plant powder. The results of the physico-chemical analysis provided important parameters in detecting adulteration or improper handling of drugs. Qualitative and quantitative analysis in the plant confirmed the presence of many important bioactive phytochemicals. Bioactivity study indicated the anti-inflammatory potential of the plant comparable to that of the standard Aspirin. Further work should be carried out to isolate, purify and characterize the active constituents responsible for the specific activity of the plant and to elucidate the possible mechanism of action of the extract. Keywords: Premna, Phytochemical, Pharmacognostical, Physio-chemical, Bioactivity, Organoleptic
Publication date: 01/02/2024

https://ijbpas.com/pdf/2024/February/MS_IJBPAS_2024_7779.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.2.7779