ABSTRACT

Cancer is nothing but the anonymous growth of tissues and improper vascular supply to the body. Plant based medicines are grabbing attraction as an efficient source of anticancer pharmacophores because of its easy availability, comparatively cheaper and least side effects. World Health Organization is nowadays encouraging the applications of ancient medicines having great efficiency and least toxicity. In present review attempted comprehensive study related to a plant having anticancer activities along with its chemical compositions such as flavonoids, saponins, curcuminoids, etc as well as its possible mechanism of action against carcinoma cell lines like, apoptosis via., intrinsic and extrinsic pathways, cell cycle disruption and the levels of various vital parameters-reactive oxygen species (ROS), vascular endothelial growth factor (VEGF) and cyclin dependent kinases (CDKs). The constituents from the different parts of Glycyrrhiza glabra are safe for its pharmaceutical implementation for the treatment of cancer and its variable mechanisms of action against different carcinoma cell lines are making it an efficient plant based pharmacological scaffold for the treatment of cancer. Keywords: Carcinoma, apoptosis, Glycyrrhiza glabra, Reactive Oxygen Species, Vascular Endothelial Growth Factor
Publication date: 01/02/2024

https://ijbpas.com/pdf/2024/February/MS_IJBPAS_2024_7729.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.2.7729