ABSTRACT

Introduction: Studying the chemistry of the urine with regard to the minerals that cause stones will give a solid indicator of the likelihood of stone formation. In ethylene glycol-induced nephrolithic rats, hypercalcinuria may be a factor that favours the formation of calcium phosphate crystals from urine precipitation and nucleation Methods: It is possible to predict the possibility of stone development by analysing the urine's chemistry in relation to the minerals that lead to stones. The development of calcium phosphate crystals from urine precipitation and nucleation may be aided by hypercalcinuria in ethylene glycol-induced nephrolithic rats.A renal calculus is1% and 0.75 percent of ethylene glycol, administered for 28 and 5 days, respectively, were used to generate the changes. In a preventive study, extract was administered at two different doses of 200 mg/kg and 400 mg/kg for 28 days. In a curative study, the same doses of extract were administered for 14 to 28 days. Numerous parameters have been evaluated, including creatinine, urea, and uric acid in the serum and oxalate, calcium, and phosphate in the urine. Results: When ethylene glycol and ammonium chloride intoxicated rats were compared to the control group, thelevels of biochemical parameters were elevated. When the extract was administered at doses of 200 and 400 mg/kg, biochemical parameters (urine:BUN, serum, urea, creatinine, calcium oxalate, and phosphate). Conclusion: Rats were prevented from developing nephrolithiasis caused by ethylene glycol by oral administration of a methanolic extract of punica granatum peel. The stimulated animals' oxalate synthesis is reduced by the protective action of MEPP. These findings imply that MEPP offers therapeutic protection against oxidative stress brought on by calcium oxalate accumulation. Keywords: Punica granatum, Nephrolithiasis, Calcium oxalate, Urolithiasis
Publication date: 01/01/2024

https://ijbpas.com/pdf/2024/January/MS_IJBPAS_2024_7725.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.1.7725