ABSTRACT

Skin acts as a major target as well as a principal barrier for topical/transdermal drug delivery. Despite the many advantages of this system, the major obstacle is the low diffusion rate of drugs across the stratum corneum. Several methods have been tried to increase the permeation rate of drugs temporarily. One simple and convenient approach is application of drugs in formulation with elastic vesicles i.e., ethanolic liposomal vesicles (Ethosomes). Ethosomes have been found to be much more efficient in delivering drug to the skin; Ethosomes are the non-invasive drug delivery carriers that enable drugs to reach the deep skin layers finally delivering to the systemic circulation. For optimal skin delivery, drug should be efficiently entrapped within ethosomal vesicles. Ethosomal drug delivery system is a new state of the art technique and easier to prepare in addition to safety and efficacy. Ethosomes have become an area of research interest, because of its enhanced skin permeation, improved drug delivery, increased drug entrapment efficiency etc. Keywords: Ethosomes, Transdermal delivery, Skin, Vesicles, Phospholipid, Ethanol
Publication date: 01/01/2024

https://ijbpas.com/pdf/2024/January/MS_IJBPAS_2024_7681.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.1.7681