ABSTRACT

A layer of endothelial cells surrounds the highly organised extracellular matrix (ECM) and valve interstitial cells (VIC) that make up adult heart valves. The ECM of the valves is stratified into elastin, proteoglycan-, and collagen-rich layers that provide the leaflets and supporting structures unique biomechanical capabilities. They are each uniquely created to guarantee optimum performance in relation to their function during the cardiac cycle. In this article, we outline the key structural characteristics that, in our opinion, are crucial for comprehending heart valve function. These characteristics will also have a significant impact on how heart valve disease is treated. They may help to advance reconstructive methods while also expanding their expertise of the design of partial or alternative valves. Understanding the macro- and microstructure of the heart valve may also be useful for heart valve engineering procedures. Keywords: Tricuspid valve, Mitral valve, Cardiovascular diseases
Publication date: 15/12/2023

https://ijbpas.com/pdf/2023/December/MS_IJBPAS_2023_DECEMBER_SPCL_1017.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.12.1017