ABSTRACT

Introduction: The intensive care unit is an integral part of a Teaching hospital, for appropriate care of critically ill patients. Most of the patients admitted to ICU will have pre-existing infections and are prone to develop new infections. number of antimicrobials prescribed for patients in the ICU is approximately 10 times more than those prescribed for patients in other wards of the hospital. Objectives: The present study evaluated the local prevalence of infections, and the pattern of antimicrobial utilization in an ICU of a teaching hospital in Vijayapura, Karnataka. Methods: a prospective observational study conducted for the period of two months [01-06 -2019 to 31- 07-2019]. The data were obtained from ICU of a teaching hospital in Vijayapura, Karnataka. Clinical and demographical information, antimicrobial agents probed, route of administration, mean duration of antimicrobials prescribed, duration of stay and the expenses incurred by the patient, associated co- morbidities etc. were collected. The utilisation of the class of anti-microbial agents was performed as per WHO-ATC classification. Results: The present study included a total of 40 ICU patients in that 32[80%] were male and 8[20%] were female. The majority of the patients belonged to 61-70 years of age. The mean duration of admission of patients in the ICU was 9 days. 34[85%] were medicine cases and 6[15%] were surgical cases. The most frequently prescribed AMA among the 40 cases was Metronidazole, followed by the FDC of Piperacillin+Tazobactam, Ceftriaxone, FDC of Amoxicillin + Clavulanic acid, Ornidazole and Ofloxacin. 43.0% of patients received 2 AMAs. The most utilized common AMAs were Metronidazole, Piperacillin+ Tazobactam, and Ceftriaxone whose utilization was 19.6, 17.3, and 12.4 DDD/100 bed days respectively. Conclusion: Based on the local prevalence of organisms and their susceptibility pattern, every institution needs to have guidelines and policies for the use of antibiotics. These recommendations help the physician in making appropriate prescriptions. Keywords: Antimicrobial agents, DDD/100 bed days, drug utilization, Intensive Care Unit
Publication date: 15/12/2023

https://ijbpas.com/pdf/2023/December/MS_IJBPAS_2023_DECEMBER_SPCL_1012.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.12.1012