ABSTRACT

Fixed dose combination (FDC) has two or more active components in a single dosage form. There are several advantages that support FDCs. These include minimizing the risk of undesirable drug effects improving therapeutic effectiveness, offering pharmacokinetic benefits, reducing the dose of specific medications, and slows down resistance to drugs. Teneligliptin (20 mg) and Pioglitazone (15 mg) are recommended to improve glycaemic control in adult patients with insulin resistance. Individual quantitation of Teneligliptin (TNG) and Pioglitazone (PIO) is done using analytical methods. This review will emphasize on recent advances in analytical methodologies for assessing TNG and PIO because no method for this combination has been reported. However, UV, stability indicating RP-HPLC and HPTLC methods have been reported for Teneligliptin and Pioglitazone individual and along with other drugs. Keywords: FDCs, Analytical techniques, RP-HPLC, HPTLC, Stability indicating methods
Publication date: 01/12/2023

https://ijbpas.com/pdf/2023/December/MS_IJBPAS_2023_7616.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.12.7616