ABSTRACT

In the present work new antimicrobial agents based on 1,3,4- oxadiazole nucleus were synthesized and evaluated. All the compounds were obtained in 64-71% yields using the reaction conditions. The compounds exhibited the peaks of aromatic C=C stretching, C-H stretching, C-N and C=N stretching and C-O stretching. The compounds were evaluated for anti-microbial potential using cup and plate method against gram positive (Bacilus subtilis and Staphylococcus aureus) and gram negative bacteria (Escherichia coli and Pseudomonas aeuroginosa). Compounds containing nitro group (5b, 5c & 5d) were found to be the most potent against all the pathogenic bacteria. The presence of NH2 and OH groups at para position was more effective than that at ortho position in the compounds. Keywords: Oxadiazole, antimicrobial, zone of inhibition, hydrazide, aromatic acid
Publication date: 01/12/2023

https://ijbpas.com/pdf/2023/December/MS_IJBPAS_2023_7615.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.12.7615