ABSTRACT

Aim: The objective of the present work was to develop, characterize and evaluate the sertaconazole nitrate loaded emulgel that release the drug in controlled manner. Sertaconazole nitrate is an imidazole derivative, act as fungistatics, fungicidal, antibacterial, anti-inflammatory and antipruritic. The novel system of drug delivery offers a means of improving effectiveness of incorporated drugs. The goal of any drug delivery system is to provide a therapeutic amount of drug to the proper site in the body to achieve promptly & then maintain desire drug concentration. Method: Gel was prepared using different polymers such as carbopol 934 and HPMC, followed by preparation of emulsions and finally mixed together. Emulgel was evaluated for physical appearance, pH, spreadability, extrudability, viscosity, swelling index, drug content, in vitro release study, kinetic analysis of release data, and stability study. Results: Evaluation parameters were in acceptable range with good physical appearance and the pH in the range of 5 to 6. The results show that the with spread ability in range of 19.8 -22.5cm. Among all formulations of emulgel F4 was having high swelling index (62%). Spread ability was lies between 19.8- 22.5. In vitro drug release was conducted. Stability study revealed that emulgel were stable at room temperature and must will be stored in cool and dry place. Keywords: Sertaconazole nitrate, controlled drug release, gelling agent, Topical delivery
Publication date: 01/12/2023

https://ijbpas.com/pdf/2023/December/MS_IJBPAS_2023_7225.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.12.7225