ABSTRACT

A simple, specific, accurate and precise UV spectrophotometric method has been developed for the simultaneous estimation of Mometasone Furoate monohydrate and Fluticasone Propionate in pharmaceutical dosage form. The absorption maxima of the Mometasone Furoate monohydrate and Fluticasone propionate were found to be 248 nm and 236 nm respectively using Acetonitrile as solvent. This method obeys Beer’s law in the employed concentration range of 2-10?g/ml and 1-6?g/ml for Mometasone Furoate monohydrate and Fluticasone propionate respectively. Different analytical performance parameters such as linearity, precision, accuracy, limit of detection (LOD) and limit of quantification (LOQ) were determined according to ICH guidelines. The LOD of Mometasone Furoate monohydrate and Fluticasone propionate was found to be 0.060?g/ml and 0.42?g/ml respectively and LOQ of Mometasone Furoate monohydrate and Fluticasone propionate was found to be 0.182?g/ml and 0.321?g/ml respectively. Keywords: UV, Simultaneous estimation, Mometasone Furoate, Fluticasone Propionate, linearity
Publication date: 01/12/2023

https://ijbpas.com/pdf/2023/December/MS_IJBPAS_2023_7162.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.12.7162