ABSTRACT

The aim the study is to formulate Bilayer tablets of Nimodipine and Metformin. Nimodipine as immediate release to lower the blood pressure and metformin as controlled release layer for type 2 diabetes mellitus. Nimodipine is a calcium channel blocker used to prevent “vasospasms” include cerebral ischemia. Metformin ability was to suppress the production of glucose in liver and increase the absorption of glucose intake in gut wall. Crospoidone as superdisintegrant nimodipine layer is developed with direct compression. The controlled release of metformin layer was prepared by using polymers like HPMC K-100M, SCMC, sodium alginate, and Eudragit RLPO, RS100, RSPO. These formulations were prepared by wet granulation method and compressed using 19 mm punch of 16 station rotary press. The prepared granules were evaluated by pre and post compression parameters like bulk density, tapped density, Carr’s index angle of repose, Hausner’s ratio, Friability, hardness, thickness, weight variation, drug content and in vitro dissolution. The FTIR studies shows that no interaction between drug and excipients. The nimodipine layer releases immediately within 15 min. Metformin controlled release layer of F9 Formulation release 85.15% up to 20 hrs. The best fit formulations subjected for stability studies showed no significant changes stored at 45?c /75RH for 1 month according to ICH guidelines. Keyword: Nimodipine, metformin, type 2 diabetes mellitus, bilayer, wet granulation method
Publication date: 15/10/2023

https://ijbpas.com/pdf/2023/October/MS_IJBPAS_2023_OCTOBER_SPCL_10351.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.10.1035