ABSTRACT

Deltamethrin (DTM) is a type II pyrethroids, it can adversely affect the male reproductive system by disturbing the steroidogenesis and spermatogenesis. However the consequence of prepubertal DTM intoxication and their impact on adult stage are not known. Current study aimed to investigate the significances of male reproductive parameters following DTM exposure from prepubertal stage to adult stage. Wherein prepubertal rats were treated with 3mg or 6mg/kg/day was given from PND 23 to PND 90 by oral gavage. Exposure of prepubertal rats to the DTM resulted in the significant weight loss in the animal and reduced sperm motility, sperm count, sperm viability and suppressed serum testosterone levels. Further DTM intoxicated groups also showed the reduced steroidogenic enzymes (3? HSD and 17? HSD levels) inn testis. Sperm morphological abnormalities and sperm DNA damage were observed along with the histopathological changes in the rat testis of DTM exposed groups. In conclusion, Deltamethrin treatment in the prepubertal rats induced the apparent reprotoxic effects at their adulthood it was confirmed by the observed adverse effects on reproductive organs. Keywords: Prepubertal rats, Deltamethrin, Reproductive toxicity, DNA damage
Publication date: 01/11/2023

https://ijbpas.com/pdf/2023/November/MS_IJBPAS_2023_7600.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.11.7600