ABSTRACT

The present work proposes to provide a eco- friendly UV spectrophotometric technique for the determination of Duloxetine hydrochloride in pharmaceutical tablets, a multivariate calibration method is used. The multivariate calibration method measures the sample absorbance at various wavelengths for more precise measurements. The UV spectrophotometric method was created, and method validation was completed. All validation parameters complied with ICH standards. The current study targets on the development of UV spectrophotometric method in First derivative mode for Duloxetine hydrochloride in bulk and pharmaceutical formulation employing multivariate calibration technique. Multivariate calibration technique utilizes the linear regression equations to correlate the relationship between concentration and amplitude at five different wavelengths, the multivariate calibration technique increases the correlation and reduces instrumental variations. Duloxetine hydrochloride showed absorption maximum at 216 nm with water as diluent. The results were treated statistically. The analytical Eco scale, Agree metrics, and Green analytical procedure index was used to assess the method's greenness scores. Keywords: Duloxetine hydrochloride, Multivariate Linear Regression Analysis, Validation, UV spectrophotometry, Greenness
Publication date: 01/11/2023

https://ijbpas.com/pdf/2023/November/MS_IJBPAS_2023_7591.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.11.7591