ABSTRACT

The Research provides a Q-absorbance ratio method for determining diclofenac sodium and famotidine in their combined pharmaceutical dosage form that is simple, sensitive, quick, accurate, precise, and cost-effective. The absorbance ratio method compares absorbance at two wavelengths, one of which is an iso-absorptive point and the other which is the ?-max of one of the two components. In methanol, the iso-absorptive point for diclofenac sodium and famotidine is 279.20 nm. The second wavelength is 282 nm, which is diclofenac sodium's ?-max in methanol. Linearity was determined in the concentration ranges of 10-20 ?g/ml for diclofenac sodium and 2-12 ?g/ml for famotidine. The ratio of absorbance at the iso-absorptive point and at the ?-max of diclofenac sodium was used to calculate the drug concentration. Because there was no interference, the method was effectively applied to tablet dosage form. Recovery investigations have confirmed the findings of the research. Keywords: Iso-absorptive point, Diclofenac Sodium, Famotidine
Publication date: 01/11/2023

https://ijbpas.com/pdf/2023/November/MS_IJBPAS_2023_7571.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.11.7571