ABSTRACT

The main cause of gelatin capsule instability is the deleterious effects of temperature and relative humidity fluctuations, on the mechanical integrity of the capsule shells, which can also have a severe impact on the fill material. Additionally, the selection of fill materials is severely constrained by their unique chemical makeup, physical characteristics, or hygroscopicity. The hunt for a superior substitute capsule shell material has been motivated by additional reports of unpredictably disintegrating and dissolving hard gelatin capsules in experimental investigations. The current review intends to give an overview of the Hydroxyl Propyl Methyl Cellulose (HPMC) as a capsule shell material whose physicochemical, pharmaceutical biopharmaceutical properties, in vitro/ in vivo performance, storage and stability are superior to gelatin capsules. The HPMC capsule widens the options for choosing various types of fill materials and offers a highly adaptable and widely accepted platform that can address many issues now plaguing the pharmaceutical and nutraceutical sectors. A new section on the impact of several conditions on the in vitro dissolution studies of HPMC capsules is introduced in the present topic. There are no adverse effects in in vitro/in vivo studies of HPMC capsules in aqueous medium. However, improvements in the manufacturing and filling of HPMC capsule shells as well as thorough research on the impacts of many parameters on their in vitro/in vivo studies is desired to establish their superiority over hard gelatin capsules in future. Key works: Gelatin capsule shell, Problems associated with Gelatin, Hydroxy Propyl Methyl Cellulose (HPMC) as capsule shell and its advantages
Publication date: 01/11/2023

https://ijbpas.com/pdf/2023/November/MS_IJBPAS_2023_75581.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.11.7558