ABSTRACT

Rare skin responses that can be fatal include toxic epidermal necrolysis (TEN) and Stevens- Johnson syndrome (SJS), which are frequently brought on by specific drugs. All age groups are affected, although those with HIV, autoimmune illnesses, immunocompromised patients, and those with underlying malignancies are more severely affected. SJS and TEN are signs of a medication reaction, and carbamazepine is frequently to blame. The most frequently implicated medicines in Southeast Asia were all carbamazepine-related. According to data from the Food and Drug Administration, carbamazepine and allopurinol were the second- and third-most popular medications in the Philippines, respectively. Phenytoin. Purpuric macules, target-like lesions, skin detachment, and a blistering exanthema with fast development are the hallmarks of SJS and TEN. Oxcarbazepine (OXC) cross-sensitivity was present in around 25–33% of patients with Carbamazepine (CBZ) hypersensitivity, while CBZ hypersensitivity was present in about 27%–70% of patients with OXC hypersensitivity. Keywords: Carbamazepine, Epidermal necrolysis
Publication date: 01/11/2023

https://ijbpas.com/pdf/2023/November/MS_IJBPAS_2023_7547.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.11.7547