Heterocyclic compounds form the main family of organic compounds. These are of enormous
importance for a variety of synthetic, pharmaceutical, and industrial applications and are
known for their biological activities. Oxadiazole or furadiazole is a five-membered ring
containing two carbons, one oxygen atom, two nitrogen atoms, and two double bonds. They
are derived from furan by replacing two nitrogen atoms (N =) with two methylene groups (=
CH). The particular structural feature of the 1,3,4-oxadiazole ring with pyridine nitrogen
atom type is advantageous for binding effectively with various enzymes and receptors in
biological systems through numerous weak interactions, thereby exhibiting various
pharmacological activities. Compounds containing the 1,3,4-oxadiazole moiety have recently
received attention for their antiviral, anti-inflammatory, anti-tuberculous, anti-cancer, anti-
parasitic, enzyme-inhibiting, antioxidant, anti-bacterial, and anti-fungal potentials. These are
the results of recent developments in the synthesis and anti-tubercular activity of 1,3,4-
oxadiazole candidates over the past 15 years. It is believed that this review will be of great
help for new ideas in the search for rational designs for the development of more active and
less toxic 1,3,4-oxadiazole-based drugs as an anti-tubercular.
Keywords: 1,3,4-Oxadiazole, Anticancer, Anti-microbial. Anti-oxidant, Furadiazole,
Anti-tubercular
Publication date: 01/11/2023
https://ijbpas.com/pdf/2023/November/MS_IJBPAS_2023_7543.pdf
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https://doi.org/10.31032/IJBPAS/2023/12.11.7543
