ABSTRACT

Neurodegenerative disorders are one of the greatest threats to humankind as they inflict on millions of people globally ensuing debility dementia and neurobehavioral derangement. Aging, oxidative stress, excitotoxicity, neuroinflammation, exposure to neurotoxicants and heavy metals etc. are some of the principal elements contributing to neurotoxicity. Antioxidants play a promising role in curbing free radical-mediated induced by oxidative stress and neurotoxins. Herbal medicines and phytocompounds being the powerhouse of antioxidants are propitious in treating neurodegeneration with added perquisites as they’re nearly devoid of side effects. By embracing methods like drug discovery, combinatorial chemistry, through other modern means, these phytocompounds may be effectively developed into potential drug moieties that would aid in handling these complex diseases in a better manner. The molecular face aluminum-mediated neurotoxicity combined with a bunch of selected herbs and a few potential phytocompounds and their protective role in aluminium-mediated neurotoxicity have been mentioned in this article. Keywords: Aluminium, Neurodegeneration, Phytocompounds, oxidative stress, neurotoxicity
Publication date: 01/11/2023

https://ijbpas.com/pdf/2023/November/MS_IJBPAS_2023_7533.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.11.7533