ABSTRACT

This study investigated how glycethosomes and Ethosomes promote intracellular and extracellular drug transport using imaging and cell line studies. This study prepares Passiflora foetida ethosomal gel and glycethosomal dispersion and evaluates their vesicle shape, size, PDI, ZP, EE, and in vitro permeation. Using modified heating methods, Ethosomes (10–40%) and soy phosphatidylcholine (1-3%) were synthesized. Next, Passiflora foetida was described and put on ethanolosomes. Passiflora foetida-loaded Ethosomes were 103±13-345±11 nm in size, with PDI ranging from 0.104 to 1.53 and glycethosomes from 1.53 to 0.293. ZP ranged from 16.6 to 40.1 mV and -18 to -43 mV. Optical and transmission electron microscopy showed unilamellar structure. Glycethosomes and Ethosomes had 42.5% to 90.01 % EE. The physicochemical features of Passiflora foetida-loaded Ethosomes dispersion after carbapol 934P was added to create a gel were studied. A Passiflora foetida-loaded ethosomal gel and Herbal drugs may be delivered through Ethosomes. Keywords: Development, Evaluation, Herbal Ethosomes, Passiflora foetida Linn. And Psoriasis
Publication date: 15/10/2023

https://ijbpas.com/pdf/2023/October/MS_IJBPAS_2023_OCTOBER_SPCL_1054.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.10.1054