ABSTRACT

Purpose: The objective of this systematic review is to summarize the research information regarding the usage of phytoconstituents in the treatment of rheumatoid arthritis disease. Method: The research information is collected from online electronic databases like Scopus, PubMed, Science Direct, DOAJ, and J gate using search terms like rheumatoid arthritis OR inflammatory arthritis OR rheumatism OR arthritis OR rheumatic OR polyarthritis. The search strategy has been set considering full-text articles in the English language using rodent models in their study. The review protocol is registered on PROSPERO, and approved on July 12, 2023 (registration no: CRD42023424094). Result: From the search results 23 articles met the inclusion criteria for the review. These articles were analyzed for the rodent species and strain used, phytoconstituents which improved the paw volume, paw edema and reduction of oxidative stress, amelioration of inflammatory cytokines, and joint swelling. Discussion: The efficacy of phytoconstituents in ameliorating oxidative stress, paw volume, joint swelling, paw edema, and inflammatory cytokines in various models of experimental rheumatoid arthritis disease is manifested compositely in 23 studies. Keywords: rheumatoid arthritis; phytoconstituents, rodent models, inflammatory arthritis
Publication date: 15/10/2023

https://ijbpas.com/pdf/2023/October/MS_IJBPAS_2023_OCTOBER_SPCL_1036.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.10.1036