ABSTRACT

This systematic review highlights the potential of antioxidants as therapeutic intervention in dry eye disease. Preclinical reports assessing the effect of plant based and synthetic antioxidants against dry eye disease was collected from online electronic databases like Scopus, PubMed, Science direct, DOAJ, and Jgate. The review protocol was registered on PROSPERO, registration no. CRD42023420934. The systematic review followed PRISMA approach for including reports and all reports were appraised for risk of bias using the SYRCLE’s RoB tool. From the search results 26 articles met the inclusion criteria for the review. These articles were analyzed for the rodent species and strain used, antioxidants which improved the tear volume, restore conjunctival goblet cells, amelioration of inflammatory cytokines like TNF-?, IL-1?, NLRP3 and reduction of oxidative stress. The studies reported in this review insinuates the target of antioxidants in dry eye disease and their mechanism of action against oxidative stress, corneal irregularity, ocular surface inflammation apoptosis and tear secretion. These repots compositely suggest that antioxidants can ameliorate the negative effects of dry eye disease and improve the tear secretion to maintain homeostasis. Keywords: Dry eye disease; keratoconjunctivitis sicca; meibomian gland dysfunction; antioxidants; rodent studies
Publication date: 15/10/2023

https://ijbpas.com/pdf/2023/October/MS_IJBPAS_2023_OCTOBER_SPCL_1032.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.10.1032