ABSTRACT

Bilirubin is primarily produced as a by-product of hemoglobin degradation in the liver. About 60% of full-term and 80% of preterm neonates are affected by hyperbilirubinemia, making the bilirubin concentration in serum crucial for monitoring liver health and identifying hyperbilirubinemia. Potentiometric sensor is used for the determination of free bilirubin which has a linear response range of 0.1 ?M to 1000 ?M bilirubin. This range includes the 5.0-500 ?M range of clinically significant bilirubin levels in serum. Despite the presence of additional blood anions in the serum such as lactate, pyruvate, deoxycholate, phosphate, and chloride, the polymeric ion-selective membrane of the sensor exclusively detects "unbound" or free ionic bilirubin. The sensor responds quickly to the change in bilirubin concentration which further improves the usability of this sensor. Keywords: Bilirubin, Ion selective electrode, Selectivity, Hyperbilirubinemia, Potentiometry
Publication date: 15/10/2023

https://ijbpas.com/pdf/2023/October/MS_IJBPAS_2023_OCTOBER_SPCL_1027.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2023/12.10.1027