ABSTRACT

Medicinal plants have been used for centuries to treat numerous diseases and contain bioactive compounds with potential curative effects. Based on ethnobotanical information, phytochemical and biological studies of medicinal plants have allowed the development of valuable drugs. Typha australis Schum & Thonn is a little-studied plant native to India. It is desired to determine the presence of secondary metabolites such as flavonoids and tannins, which are phenolic compounds with antioxidant and bactericidal properties. The objective of the present study is to characterise the phytochemistry, pharmacology, cytotoxic effects, and antibacterial and antioxidant efficacy of T. australis leaf extracts. Phytochemical analysis was done using standard procedure colour identification tests, and the antibacterial activity was evaluated using the broth microdilution technique. The level of antioxidant activity was measured using the DPPH free radical test. High-performance liquid chromatography was used to determine the chemicals in the leaf extract. By doing a phytochemical analysis, the flavonoids, phenols, and tannins were found. Antimicrobial activity against Klebsiella pneumoniae (8mg/mL), Candida dubliniensis (1044 mg/mL) and Candida metapsilosis (65 mg/mL), and Staphylococcus epidermidis (4mg/mL) can be associated to the chemical compounds found in the ethanolic extract of T. australis leaves. This shows that there may bea way to treat highly resistant yeasts and bacteria. The antioxidant activity of ethanol extract was IC50 was 18.67g/mL The findings suggested that the T. australis extract does not interfere with cell division because none of the tested doses proved dangerous. This research demonstrated the antibacterial and antioxidant properties of T. australis ethanolic extract and its non-toxicity, suggesting the possibility of novel antibiotics for treating infections. Keywords: T. australis, leaf extracts, Phytochemistry, Pharmacology, HPLC, Antimicrobial activity, Antioxidant activity
Publication date: 15/10/2023

https://ijbpas.com/pdf/2023/October/MS_IJBPAS_2023_OCTOBER_SPCL_1024.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.10.1024