ABSTRACT

Essential oils and fixed oils are established since years in the clinical management of inflammatory disorders. Present study was designed to formulate and evaluate herbal based anti-inflammatory ointment to reduce the inflammation of the skin and muscle. Ointment was formulated with combination of selected of essential and fixed oils which have been reported as potential anti-inflammatory agents. Three combinations; F1, F2 and F3 were prepared and F3 was selected based on the stability and activity study reports. Anti-inflammatory activity was evaluated by carrageenan induced paw edema model in mice. Ointment was applied externally, once in two hours three times a day and once in six hrs. for consecutive day, after the onset of inflammation. The formulation (F3) showed enhanced anti-inflammatory activity by reducing the edema and inflammation by 85% compared to the standard Dual scan Gel which showed 70% reduction (contains diclofenac, diethylamine, oleum lini, methyl salicylate & menthol). From the study, it is concluded that, formulation F3possesses potential anti- inflammatory activity compared to conventional anti-inflammatory gel and can be a promising formulation for external application to treat inflammation. Keywords: Herbal, Ointment, Inflammatory Disorders, Essential Oil
Publication date: 15/10/2023

https://ijbpas.com/pdf/2023/October/MS_IJBPAS_2023_OCTOBER_SPCL_1008.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.10.1008