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PRECLINICAL EVALUATION OF HYDROALCOHOLIC EXTRACT OF LEAVES OF CATHARANTHUS ROSEUS FOR ITS EFFECT ON THE CENTRAL NERVOUS SYSTEM
Authors: Roy S , DAS D, SARKAR P, DUTTA S, JANA P, ROY SD, MAJUMDAR M, ROY P, SARKAR NS, SAHA A, SINGH S, BAISYA O, GHOSH S, ROY SANTANU AND CHATTOPADHYAY S

ABSTRACT
Catharanthus roseus is a medicinal plant of the Apocynaceae family. It mainly contains alkaloids. From previous research, it is found that these alkaloids had anticancer, antidiabetic, and antihypertensive effects. In this experiment, the study was focused to evaluate the effect of Catharanthus roseus on the central nervous system of albino Wistar rats. The hydroalcoholic extract of the leaves of Catharanthus roseus was formed by a cold percolation process. The hydroalcoholic extract of the leaves of Catharanthus roseus extract showed a promising effect on the central nervous system of the rat. It showed its central nervous system depression effect as well as smooth muscle relaxant activity also. The potency of Catharanthus roseus was also compared with the marketed standard drug. The research outcomes indicate that the hydroalcoholic extract of Catharanthus roseus has a satisfactory effect as a CNS depressant and smooth muscle relaxant. Keywords: Catharanthus roseus, hydroalcoholic extract, albino Wistar rat, CNS depressant activity, smooth muscle relaxant activity
Publication date: 15/10/2023
    https://ijbpas.com/pdf/2023/October/MS_IJBPAS_2023_OCTOBER_SPCL_1004.pdf
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https://doi.org/10.31032/IJBPAS/2023/12.10.1004

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