ABSTRACT

The present study states that the traditional medicinal plant clitoriaternatea which is having the nootropic activity by formulating as a lozenges. The present study states the design and development of poly herbal lozenges. It is the advanced method of medication delivery which has the excellent future for both local and systemic effect. A lozenge does not pass through the digestive system and they should be released in controlled manner which releases over extended time period. Hard boiled lozenges are most frequently used and popularly known among the customers to promote patient compliance which ensuring the patient safety and efficacy. Lozenges are the OTC (over the counter) medication that does not requires prescription. Some drugs require a prescription, while others are given by a doctor. The clitoria ternatea has prominent effect on CNS which have indegious character of enhancing nervous system activities like person’s speech, mood, ability to grassing and remembering, intellectual behavior and recall information. The clitoria ternatea is used in the alzheimer’s disease instead of using conventional medicine because of the adverse effects in addition to their pharmacological activity. In our present study we have developed a novel formulation to lozenges and evaluated the final product which was obtained at the end of formulation. The herbal powders of Clitoria ternatea, Curcuma longa and Glycyrrhiza glabra are used in the present formulation. The herbal powders were done for Preformulation studies. Corn syrup (Binder) and sugar (candy base) used in the formulation as excipients. The lozenges were formulated by using the heating and congealing method. The formulated lozenges were evaluated by tests like Weight variation, Hardness, Thickness, Diameter, Friability, pH and In-Vitro Dissolution studies. Keywords: Hard Boiled Lozenges (HBL), Clitoria ternatea, Curcuma longa, Glycyrrhzia glabra, Nootropic, Alzheimer’s, CNS, OTC, In-Vitro Dissolution Studies
Publication date: 15/10/2023

https://ijbpas.com/pdf/2023/October/MS_IJBPAS_2023_OCTOBER_SPCL_1001.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.10.1001