ABSTRACT

The design and synthesis of mutual prodrugs for nonsteroidal anti-inflammatory drugs (NSAIDs) have been given much attention by medicinal chemists. NSAIDs are the most widely used prescribed and over the counter (OTC) medications. This review article focuses on the mutual prodrugs of NSAIDs with reduced GIT toxicity. Many researchers have synthesized the Prodrugs of NSAIDs and evaluated for their biological activities. The present review provides an in-depth view of work done so far on prodrugs of NSAIDs and its biological activities covering analgesic, anti-inflammatory, and ulcerogenic activities. Majority of the efforts were given by medicinal chemist to design ester, amide and mutual prodrugs of for masking the free carboxylic groups to protect the gastrointestinal tract (GIT) The free acidic group is responsible for the GIT toxicity because it generates the oxygen reactive species. Commonly, a prodrug is synthesized from a parent drug by covalently linking it, with or without a spacer, to a pharmacologically active promoiety or ester and amide prodrugs of NSAIDs, which can be cleaved enzymatically and/or chemically upon administration, releasing the parent drug. Keywords: NSAIDs, Prodrugs, analgesic, anti-inflammatory, ulcerogenicity, OTC
Publication date: 01/10/2023

https://ijbpas.com/pdf/2023/October/MS_IJBPAS_2023_7509.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.10.7509