ABSTRACT

Drugs having poor aqueous solubility present one of the major confronts better absorption for good bioavailability of such drugs. Solid dispersion of Hydrochlorothiazide and Telmisartan in a fixed dose combination was prepared. The major problem with these drugs is their low aqueous solubility, which results into poor bioavailability after oral administration. The purpose of this study was to prepare and characterize solid dispersions of the poorly water soluble antihypertensive agent. Hydrochlorothiazide and Telmisartan with water soluble carriers such as PEG-4000 to improving its aqueous solubility and rate of dissolution. The solid dispersions of drug were prepared by solvent evaporation technique and evaluated by FTIR, X-ray diffraction and DSC analyses and in-vitro dissolution characteristics. The data were compared with that of physical mixture of hydrochlorothiazide and Telmisartan and of pure hydrochlorothiazide. The results showed reduction in particle size, change from crystalline form to amorphous form and enhanced the dissolution rate of hydrochlorothiazide from solid dispersion as compared to physical mixture as well as pure hydrochlorothiazide. The findings of the present study propose that the novel drug-drug solid dispersion approach is beneficial for fixed dose combinations of poorly soluble and soluble drugs to improve bioavailability of poorly soluble drugs. Keywords: Hydrochlorothiazide, Telmisartan, PEG 4000, Dissolution Enhancement, Solid Dispersion
Publication date: 01/10/2023

https://ijbpas.com/pdf/2023/October/MS_IJBPAS_2023_7503.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.10.7503