ABSTRACT

The current investigation explores the analgesic activity of Vitex negundo (VN) Linn (Verbenaceae), known as Nirgundi which is an important medicinal plant with variety of phytoconstituents having significant pharmacological activities. Oral administration of Nirgundi leaves and stem extracts (250 mg/kg) exhibited a significant reduction in acetic acid induced writhing response and methanol extract of stem showed better (74.6) activity as compared to leaves (62.8*) and control. In Hot-plate method, (VS) stem fraction (4.4) showed better activity as compared to leaf (4.0) (VL). Analgesic effect of stem extract (7.3) was more as compared to the leaves (5.7) in tail flick method. In Randall Sellitto test, leaf extract showed better activity (390) as compared to stem (340) and after 2 hours all the extracts showed decrease in analgesic activity. The results concluded that stem extract of Nirgudi possess therapeutic potential in analgesia as compared to the leaf extract. Keywords- Vitex negundo (VN), Writhing response, Tail Flick Method, anti-analgesic activity
Publication date: 01/10/2023

https://ijbpas.com/pdf/2023/October/MS_IJBPAS_2023_7474.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.10.7474