The pharmaceutical company relies heavily on oral drug delivery technology. The market has moved
from the traditional tablet/capsule form to the modern fast-dissolving tablet/capsule form. Oral solids
have lower bioavailability, which makes it difficult. Errors in the use of injections and dosages of
liquid drugs changed the focus of the study. Pharmaceutical companies need to create new oral dosage
forms to remove some limitations on known side effects. Most of these problems can be solved with
oral thin films. Currently, on the market, there are not many prescriptions for oral thin film. Despite
the uncertainty surrounding the development, approval, and penetration, the market is expected to
grow steadily over the next decade. Many people have difficulty swallowing, especially children, the
elderly, and people with dysphagia. In addition, some disorders require a quick response. The main
objective of this work was to develop a palatable film using procyclidine HCl, as well as base
ingredients such as polymers, plasticizers, sweeteners, salivary stimulants, and flavors. The films are
prepared by solvent casting method. HPMC E5 cps, can't pass film thickness. HPMC E15 has good
flexibility. The plasticizer propylene glycol cannot give the film flexibility and resistance to folding.
PEG 400 produces good flexural strength, good tensile strength, and good percent elongation. The
optimized formulation (F3) exhibits palatability, surface pH, folding resistance, instant drug release as
well as good mechanical properties.
Keyword: Mouth Dissolving Film, Immediate Release, Procyclidine HCL, Fast Degrading
Membranes, Water-Soluble Polyme
Publication date: 01/10/2023
https://ijbpas.com/pdf/2023/October/MS_IJBPAS_2023_7468.pdf
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https://doi.org/10.31032/IJBPAS/2023/12.10.7468
