ABSTRACT

Background/aim: Diabetes Mellitus is a major metabolic disorder leading to macro as well as microvascular complications including retinopathy, which is a major cause of blindness worldwide. The study was conducted to find and compare the levels of total serum sialic acid with HbA1c levels in diabetic patients with and without retinopathy. Methods: For this study, one hundred eighty patients having type 2 diabetes aged forty and above were selected based on the inclusion and exclusion criteria set for the study. Patients were divided into two groups: Group A (ninety diabetic patients having diabetic retinopathy) and Group B (ninety diabeticpatients without having diabetic retinopathy). Data was collected after informed written consent of the individuals. Findings: The mean ± SD sialic acid and HbA1c for both groups, A and B were 464·74 ± 348·18 mmol/l and 7·43 ± 1·42%, and 433·49 ± 408·64 mmol/l and 8.08 ± 1.62% respectively. There was no difference seen in serum sialic acid levels in both groups (t = 0·55, p = 0·581). However, HbA1C was found significantly lower in the group without diabetic retinopathy (t = -2·87, p = 0·005). Interpretation: Although serum sialic acid levels do increase in diabetes, there were no significant links between rising levels of serum sialic acid and the development of diabetic retinopathy. However, the opposite was found to be true for glycosylated hemoglobin. Keywords: Inflammatory Marker, Sialic Acid Diabetic Retinopathy, HbA1c Association
Publication date: 01/10/2023

https://ijbpas.com/pdf/2023/October/MS_IJBPAS_2023_7444.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.10.7444