ABSTRACT

The present study was carried out to develop controlled release Aceclofenac matrix tablets by a hydrophilic polymer such as sodium carboxy-methyl-cellulose (Na-CMC). The formulation was prepared by using Aceclofenacand Na-CMC at different ratios (1:05, 1:1, and 1:15) and the prepared drug polymers mixtures were granulated by wet granulation technique (F1, F2&F3). The prepared granules were found to have good flow properties (compressibility index, Hausner’s ratio and angle of repose). These granules are used to prepare tablets by using tablet compression maching. The prepared tablets were evaluated for post compression parameters as specified in pharmacopoeias (thickness, diameter, hardness, friability, weight variation, content uniformity, disintegration and dissolution). From the results it is observed that F2 formulation has superior quality than others and hence F2 is considered as optimesed formulation. FTIR spectra indicates there were no intractions between drug and polymer. The reproducibility of method of preparation of F2 was further confirmed by ANOVA. The results indicated that the method of preparation of controlled release tablets of Aceclofenac and Na- CMC at 1:1 ratio is reproducible and it fulfills as the parameters as per pharmacopoeias. Keywords: Aceclofenac, Na-CMC, pre and post compression parameters, FTIR, ANOVA
Publication date: 01/09/2023

https://ijbpas.com/pdf/2023/September/MS_IJBPAS_2023_7436.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.9.7436