ABSTRACT

Prenylated chalcones, such as 4-Hydroxy-derricin (4-HD) and Xanthoangelol (XA), are abundant in Ashitaba Chalcone Powder (ACP), have significant hypoglycemic potential. The chalcones acts by upregulating insulin signalling by inhibiting PTP1B, inducing Glut4- dependent glucose absorption via the LKB1/AMPK pathway, upregulating adiponectin and inhibiting ?-glucosidase and DPP-IV, differentiating 3T3-L1 preadipocytes into adipocytes via the AMPK pathway, and causing inflammation brought on by hyperglycemia. This review emphasises the Nrf2-ARE-Keap1 pathway-mediated hypoglycemic action of 4-HD and XA Keywords: Ashitaba chalcone powder, prenylated chalcones, 4-hydroxyderricin, Xanthoangelol, Nrf2, ARE, Keap1, Hypoglycemia, Angelica keiskei
Publication date: 01/09/2023

https://ijbpas.com/pdf/2023/September/MS_IJBPAS_2023_7432.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.9.7432