ABSTRACT

The aim of this research work was to develop a simple, accurate, sensitive and validated Ultra Violet (UV) spectrophotometric assay using multivariate regression method for the analysis of Rizatriptan. This multivariate calibration technique was based on equations constructed using linear regression analysis using the correlation between absorbance and concentration at five selected equidistant wavelengths. Rizatriptan had a maximum absorbance of 226 nm. The findings were statistically analysed for significance. A linear plot in the concentration range of 14-16 ?g/mL, with a regression co-efficient of 0.999 was obtained. The % RSD for intra-day and Inter-day precision were 0.2342 and 0.1537, respectively. The assay was determined and found to be 98.13% - 101.50 % w/w. Keywords: Rizatriptan, 5HT1B and 5HT1D receptors, UV spectrophotometry, Multivariate calibration, ICH guidelines
Publication date: 01/09/2023

https://ijbpas.com/pdf/2023/September/MS_IJBPAS_2023_7410.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.9.7410