ABSTRACT

Parkinson’s disease (PD) is a well-known neurodegenerative disorder characterized by dopaminergic (DA) neuron loss in the substantia nigra pars compacta. In the present study, we evaluated Anti-parkinsonian activity of Convolvulus pluricaulis (CP) in Oxotremorine (OXO) and Haloperidol induced PD in mice. PD was induced by administering OXO (0.5mg/kg S.C.) and haloperidol (2.0 mg/kg i.p.). In OXO induced model tremor, hypothermia and salivation were evaluated and behavior parameters such as locomotor activity, motor coordination and catalepsy were evaluated using actophotometer, open field test, rotarod test, horizontal bar test, bar test and hang test in haloperidol induced mice model. In OXO model Ethanol extract (EE) and aqueous extract (AE) of CP at the dose of 125 and 250 mg/kg. were significant decreases the tremor and salivation score and increases the temperature compare to disease induce group. Effect of EECP and AECP are showing promising results in OXO model. In haloperidol model EECP and AECP at the dose of 125 and 250 mg/kg significantly increases the locomotor activity, motor coordination and decreases the cataleptic behavior in bar test and increases the hanging time in hang test which indicates the better cataleptic behavior compare to disease induce group. Effect of EECP and AECP are showing better results in haloperidol model due to the presence of alkaloids, flavonoids, tropane alkaloids and scopoletin. The data show that CP extract has significant anti-parkinsonian activity and suggest that these effects may be mediated via antioxidant and neuroprotective and anticholinergic activity. Keywords: Convolvulus pluricaulis, Parkinson’s disease, Oxotremorine, Haloperidol, Anticholinergic, Antioxidant
Publication date: 01/09/2023

https://ijbpas.com/pdf/2023/September/MS_IJBPAS_2023_7404.pdf

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https://doi.org/10.31032/IJBPAS/2023/12.9.7404